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Testosterone Replacement Could Decrease Deaths in Men With Type 2 Diabetes and Testosterone Deficiency

A new study reported at the Society for Endocrinology by Professor Hugh Jones shows that men with low levels of testosterone may die sooner unless they are given testosterone replacement therapy.

AnnA Rushton

Professor Jones’ team conducted a six year study of 587 men with type 2 diabetes, splitting them into three groups: those with normal testosterone levels, those with┬álow testosterone levels and those with low testosterone levels treated with testosterone replacement therapy for two years or more during the follow up period.

The findings show for the first time that low testosterone puts diabetic men at a significantly increased risk of death. Thirty six of the 182 diabetic men with untreated low testosterone died during the six year study, compared to 31 of the 338 men with normal testosterone levels (20% vs 9%). Furthermore, only 5 of the 58 diabetic men that were given testosterone replacement therapy died during the study (8.6%), meaning they showed significantly better survival compared to the non-treated group.

It is well known that men with type 2 diabetes often have low testosterone levels, so it is important that we investigate the health implications of this. We now need to carry out a larger clinical trial to confirm these preliminary findings. If confirmed, then many deaths could be prevented every year.

This is the first study to show testosterone treatment can improve survival in men with type 2 diabetes and testosterone deficiency. Further studies now need to be carried out to fully investigate the potential therapeutic benefit of testosterone replacement in diabetic men with low testosterone.

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