Related Topics: Cancer, Features, Natural Progesterone

Tumour Growth In Childhood Cancer Inhibited by Progesterone

Science may finally be catching up with the late Dr John Lee as a new study vindicates his views on the protective effects of natural progesterone.

AnnA Rushton

This study was done at Emory University and the lead author was Dr. Donald Stein, who pioneered the use of progesterone in treating brain injuries. It shows that high doses of progesterone inhibited the growth of neuroblastoma tumors in mice without killing healthy cells. Neuroblastoma is a cancer that develops from nerve tissue, and is the most common cancer in small children.

Dr Stein and his team were working on the problem of how to make progesterone more effective when they discovered that while progesterone was protecting healthy neurons from stress effects it also killed cells in a cancer line. When they investigated this effect in mice, they found that over eight days progesterone cut tumor growth by 50 percent, without toxicity.

They explain that, “High-dose P4 [progesterone] inhibited tumor growth by suppressing cell proliferation and inducing apoptosis…” Apoptosis is programmed cell death, and a hallmark of cancer cells is that they don’t die when they’re supposed to. Progesterone also signals cells to differentiate, or develop into specific types of cells. Another hallmark of cancer cells is that they don’t differentiate.

The Emory team recently published research showing that a combination of progesterone and vitamin D works better to protect the brain than progesterone alone and are also investigating whether progesterone can help prevent the growth of glioblastomas and astrocytoma, both brain cancers.

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wellsprings | 8:33 am, August 8th, 2011

Thank you for this, and we will keep an eye out for additional information from Emory. Certainly John Lee’s description and identifying of estrogen dominance as being responsible for many hormonal imbalance conditions confirms your view of oestrogen’s effects.

jr | 8:36 pm, August 7th, 2011

Interesting, especially since progesterone’s role in brain health is coming to the forefront. Low progesterone due to annovulatory cycles exacerbates epilepsy and seizure frequency. Emory is also studying its brain-calming effects and how it may treat traumatic brain injury and addiction. In fact, some data indicate that hot flashes are estrogen withdrawal and that progesterone is important in controlling this.

I think the bottom line is that estrogen’s brain effects are largely negative (stroke, dementia, brain atrophy) and that sufficient progesterone is necessary to counterbalance estrogen excess.

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